Synthesis of Geminal Bis- and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ions
| dc.date.accessioned | 2022-09-01T09:46:08Z | |
| dc.date.available | 2022-09-01T09:46:08Z | |
| dc.date.issued | 2022-04-05 | |
| dc.identifier | doi:10.17170/kobra-202206246402 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/14122 | |
| dc.description.sponsorship | Gefördert im Rahmen des Projekts DEAL | ger |
| dc.language.iso | eng | eng |
| dc.rights | Namensnennung 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | bisphosphonates | eng |
| dc.subject | calcium | eng |
| dc.subject | coordination chemistry: O ligands | eng |
| dc.subject | phosphorus | eng |
| dc.subject | structure elucidation | eng |
| dc.subject.ddc | 540 | |
| dc.title | Synthesis of Geminal Bis- and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ions | eng |
| dc.type | Aufsatz | |
| dcterms.abstract | Geminal Bisphosphonate (BP) Esters in Ca(II) Ion Coordination. A series of geminal BPs was prepared starting from their corresponding ethyl- or isopropyl (arylmethylene)phosphonate ester precursors. Complexation with CaCl₂ yields the derived coordination compounds [Ca(H₂O)₂(L1–L3)₂]Cl₂ or [Ca(L8)Cl₂]ₙ. Their structures in the solid- (SCXRD) as well as solution-state (¹H DOSY NMR) are evaluated and comprehensively compared to literature data. The preparation and thorough characterization of a variety of (arylmethylene)phosphonate ester derivatives (S1–S7) as well as derived geminal bisphosphonate (BP) ester ligands (L1–L7) is presented. Subsequent complexation reactions of CaCl₂ with selected BPs (L1–L3) and a known aliphatic tetrakisphosphonate ester (L8) yield the respective Ca(II) coordination compounds [Ca(H₂O)₂(L1--L3)₂]Cl₂ (C1--C3) and [Ca(L8)Cl₂]ₙ (C4) for potential future application as multi-delivery systems in osteoporosis treatment. Obtained SCXRD and ¹H DOSY-NMR data provide a detailed insight into their solid- as well as solution-state structures extending the so far scarcely found X-ray studies on geminal BP-supported Ca(II) complexes. | eng |
| dcterms.accessRights | open access | |
| dcterms.creator | Köhne, Ingo | |
| dcterms.creator | Pietschnig, Rudolf | |
| dc.relation.doi | doi:10.1002/ejic.202200194 | |
| dc.subject.swd | Diphosphonate | ger |
| dc.subject.swd | Calcium | ger |
| dc.subject.swd | Koordinationslehre | ger |
| dc.subject.swd | Ligand | ger |
| dc.subject.swd | Phosphor | ger |
| dc.subject.swd | Strukturaufklärung | ger |
| dc.type.version | publishedVersion | |
| dcterms.source.identifier | eissn:1099-0682 | |
| dcterms.source.issue | Issue 17 | |
| dcterms.source.journal | EurJIC (European Journal of Inorganic Chemistry) | eng |
| dcterms.source.volume | Volume 2022 | |
| kup.iskup | false | |
| dcterms.source.articlenumber | e202200194 |
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