Aufsatz
Combined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patterns
Zusammenfassung
Controlled actuation of superparamagnetic beads (SPBs) within a microfluidic environment using tailored dynamic magnetic field landscapes (MFLs) is a potent approach for the realization of point-of-care diagnostics within Lab-on-a-chip (LOC) systems. Making use of an engineered magnetic domain pattern as the MFL source, a functional LOC-element with combined magnetophoretic “funnel”, concentrator, and “valve” functions for micron-sized SPBs is presented. A parallel-stripe domain pattern design with periodically decreasing/increasing stripe lengths is fabricated in a topographically flat continuous exchange biased (EB) thin film system by ion bombardment induced magnetic patterning (IBMP). It is demonstrated that, upon application of external magnetic field pulses, a fully reversible concentration of SPBs at the domain pattern's focal point occurs. In addition, it is shown that this functionality may be used as an SPB “funnel”, allowing only a maximum number of particles to pass through the focal point. Adjusting the pulse time length, the focal point can be clogged up for incoming SPBs, resembling an on/off switchable particle “valve”. The observations are supported by quantitative theoretical force considerations.
Zitierform
In: Small : nano micro Volume 20 / Issue 10 (2023-10-27) eissn:1613-6829Förderhinweis
Gefördert im Rahmen des Projekts DEALZitieren
@article{doi:10.17170/kobra-2024042410064,
author={Huhnstock, Rico and Paetzold, Lukas and Merkel, Maximilian and Kuświk, Piotr and Ehresmann, Arno},
title={Combined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patterns},
journal={Small : nano micro},
year={2023}
}
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2024-04-24T14:40:04Z 2024-04-24T14:40:04Z 2023-10-27 doi:10.17170/kobra-2024042410064 http://hdl.handle.net/123456789/15707 Gefördert im Rahmen des Projekts DEAL eng Namensnennung 4.0 International http://creativecommons.org/licenses/by/4.0/ ion bombardment induced magnetic patterning lab-on-a-chip magnetic domain engineering magnetic field landscapes magnetic particle transport superparamagnetic beads 530 Combined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patterns Aufsatz Controlled actuation of superparamagnetic beads (SPBs) within a microfluidic environment using tailored dynamic magnetic field landscapes (MFLs) is a potent approach for the realization of point-of-care diagnostics within Lab-on-a-chip (LOC) systems. Making use of an engineered magnetic domain pattern as the MFL source, a functional LOC-element with combined magnetophoretic “funnel”, concentrator, and “valve” functions for micron-sized SPBs is presented. A parallel-stripe domain pattern design with periodically decreasing/increasing stripe lengths is fabricated in a topographically flat continuous exchange biased (EB) thin film system by ion bombardment induced magnetic patterning (IBMP). It is demonstrated that, upon application of external magnetic field pulses, a fully reversible concentration of SPBs at the domain pattern's focal point occurs. In addition, it is shown that this functionality may be used as an SPB “funnel”, allowing only a maximum number of particles to pass through the focal point. Adjusting the pulse time length, the focal point can be clogged up for incoming SPBs, resembling an on/off switchable particle “valve”. The observations are supported by quantitative theoretical force considerations. open access Huhnstock, Rico Paetzold, Lukas Merkel, Maximilian Kuświk, Piotr Ehresmann, Arno 10 Seiten doi:10.1002/smll.202305675 Lab on a Chip Teilchen Magnetpartikelbildgebung Magnetfeld publishedVersion eissn:1613-6829 Issue 10 Small : nano micro Volume 20 false 2305675
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