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Combined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patterns

dc.date.accessioned2024-04-24T14:40:04Z
dc.date.available2024-04-24T14:40:04Z
dc.date.issued2023-10-27
dc.identifierdoi:10.17170/kobra-2024042410064
dc.identifier.urihttp://hdl.handle.net/123456789/15707
dc.description.sponsorshipGefördert im Rahmen des Projekts DEAL
dc.language.isoeng
dc.rightsNamensnennung 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjection bombardment induced magnetic patterningeng
dc.subjectlab-on-a-chipeng
dc.subjectmagnetic domain engineeringeng
dc.subjectmagnetic field landscapeseng
dc.subjectmagnetic particle transporteng
dc.subjectsuperparamagnetic beadseng
dc.subject.ddc530
dc.titleCombined Funnel, Concentrator, and Particle Valve Functional Element for Magnetophoretic Bead Transport Based on Engineered Magnetic Domain Patternseng
dc.typeAufsatz
dcterms.abstractControlled actuation of superparamagnetic beads (SPBs) within a microfluidic environment using tailored dynamic magnetic field landscapes (MFLs) is a potent approach for the realization of point-of-care diagnostics within Lab-on-a-chip (LOC) systems. Making use of an engineered magnetic domain pattern as the MFL source, a functional LOC-element with combined magnetophoretic “funnel”, concentrator, and “valve” functions for micron-sized SPBs is presented. A parallel-stripe domain pattern design with periodically decreasing/increasing stripe lengths is fabricated in a topographically flat continuous exchange biased (EB) thin film system by ion bombardment induced magnetic patterning (IBMP). It is demonstrated that, upon application of external magnetic field pulses, a fully reversible concentration of SPBs at the domain pattern's focal point occurs. In addition, it is shown that this functionality may be used as an SPB “funnel”, allowing only a maximum number of particles to pass through the focal point. Adjusting the pulse time length, the focal point can be clogged up for incoming SPBs, resembling an on/off switchable particle “valve”. The observations are supported by quantitative theoretical force considerations.eng
dcterms.accessRightsopen access
dcterms.creatorHuhnstock, Rico
dcterms.creatorPaetzold, Lukas
dcterms.creatorMerkel, Maximilian
dcterms.creatorKuświk, Piotr
dcterms.creatorEhresmann, Arno
dcterms.extent10 Seiten
dc.relation.doidoi:10.1002/smll.202305675
dc.subject.swdLab on a Chipeng
dc.subject.swdTeilchenger
dc.subject.swdMagnetpartikelbildgebungger
dc.subject.swdMagnetfeldger
dc.type.versionpublishedVersion
dcterms.source.identifiereissn:1613-6829
dcterms.source.issueIssue 10
dcterms.source.journalSmall : nano microeng
dcterms.source.volumeVolume 20
kup.iskupfalse
dcterms.source.articlenumber2305675


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